Article

Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down’s syndrome mouse model

2020-04-09

Abstract excerpt

<h4>ABSTRACT</h4> Down syndrome (DS) is the most frequent genetic cause of intellectual disability including hippocampal-dependent memory deficits. We have previously reported hippocampal mTOR (mammalian target of rapamycin) hyperactivation, and related plasticity as well as memory deficits in Ts1Cje mice, a DS experimental model. Here we report that performance of Ts1Cje mice in novel object recognition (NOR) is...

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Literature Corpus work: e8d8002f-c4f1-52ee-ae8f-48ec824d3b56
DOI: 10.1101/2020.04.08.032029

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