Article

The hunger games: sensing host arginine is essential for <i>Leishmania</i> parasite virulence

2019-08-30

Abstract excerpt

Arginine homeostasis in lysosomes is critical for growth and metabolism of mammalian cells. They employ a specific sensor (SLC38A9) that monitors intra-lysosome arginine sufficiency and subsequently up-regulates cellular mTORC1 activity. Lysosomes of macrophages (phagolysosomes) are the niche where the parasitic protozoan Leishmania resides and causes important human disease. Several years ago, we discovered that...

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Literature Corpus work: 0572dc23-5e9a-59dd-9b58-c35ba5307eb7
DOI: 10.1101/751610

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