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<i>Leishmania</i> infection triggers hepcidin-mediated proteasomal degradation of Nramp1 resulting in increased phagolysosomal iron availability

2019-10-28

Abstract excerpt

Natural resistance associated macrophage protein 1 (Nramp1) was discovered as a genetic determinant of resistance against multiple intracellular pathogens, including Leishmania . It encodes a transmembrane protein of the phago-endosomal vesicles, where it functions as an iron transporter. But how Nramp1 expression is regulated in an infected macrophage is unknown. Its role in controlling iron availability to the...

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Literature Corpus work
47560d95-25ed-57e7-98b7-db04ae04a64a
DOI
10.1101/820340
Open publication

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