Article

UBR1 Promotes Sex-Dependent ACE2 Ubiquitination in Hypertension

2024-05-25

Abstract excerpt

<h4>Background</h4> Angiotensin (Ang)-II impairs the function of the antihypertensive enzyme ACE2 by promoting its internalization, ubiquitination and degradation thus contributing to hypertension. However, few ACE2 ubiquitination partners have been identified and their role in hypertension remains unknown. <h4>Methods</h4> Proteomics and bioinformatic analysis were used to identify ACE2 ubiquitination partners in...

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Literature Corpus work: 053a36fc-453d-50a3-91bc-e6f204a755ea
DOI: 10.1101/2024.05.23.24307722

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