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Podocyte histone deacetylase activity regulates murine and human glomerular diseases

17 Feb 2019

Abstract excerpt

We identified 2 genes, histone deacetylase 1 (HDAC1) and HDAC2, contributing to the pathogenesis of proteinuric kidney diseases, the leading cause of end-stage kidney disease. mRNA expression profiling from proteinuric mouse glomeruli was linked to Connectivity Map databases, identifying HDAC1 and HDAC2 with the differentially expressed gene set reversible by HDAC inhibitors. In numerous progressive glomerular...

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PMID: 30776024
DOI: 10.1172/jci124030

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