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Article

Expression, Transcription, and Possible Antagonistic Interaction of the Human Nedd4L Gene Variant

12 Feb 2008

Abstract excerpt

Net sodium balances in humans are maintained through various ion transporters expressed along the entire nephron. Among these ion transporters, epithelial sodium channels (ENaC) located along the aldosterone-sensitive distal nephron (ASDN) play a pivotal role in the homeostasis of sodium balance. This is supported by analyses of inherited hypertensive disorders, showing that genes encoding ENaC and other...

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PMID: 18268134
DOI: 10.1161/hypertensionaha.107.102061

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