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Article

Sex-Specific Modulation of Blood Pressure and the Renin-Angiotensin System by ACE (Angiotensin-Converting Enzyme) 2.

Hypertension (Dallas, Tex. : 1979) - 1 Aug 2020

Ji Hong, de Souza Aline M A, Bajaj Bilkish, Zheng Wei, Wu Xie, Speth Robert C, Sandberg Kathryn

Abstract excerpt

We showed ACE (angiotensin-converting enzyme) 2 is higher in the kidney of male compared with female mice. To further investigate this sex difference, we examined the role of ACE2 in Ang-[1-8] (angiotensin [1-8])-induced hypertension and regulation of the renin-angiotensin system in the kidney of WT (wild type) and Ace2 KO (knockout) mice. Mean arterial pressure rose faster in WT male than WT female mice after...

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Identifiers

PMID: 32564694
DOI: 10.1161/HYPERTENSIONAHA.120.15276
PMCID: PMC7365573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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