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Article

Ubiquitin-Specific Peptidase 8 Mediates Angiotensin-II-Induced Smooth Muscle Cell Phenotypic Transformation during Hypertension via Regulating LRRC8A.

American journal of hypertension - 1 Jun 2026

Zhou Huiliang, Ge Xiong, Feng Guangrui, Liu Liang

Abstract excerpt

BACKGROUND: Leucine-rich repeat-containing protein 8 A (LRRC8A) has been uncovered to play a role in pulmonary vascular remodeling during hypertension. The present study aims to investigate a novel mechanism involving LRRC8A in smooth muscle cell (SMC) phenotypic transformation under the hypertension context. METHODS: Angiotensin (Ang)-II-treated human aortic SMCs were established as the cell model under the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41499430
DOI: 10.1093/ajh/hpaf250

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USP8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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