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Article

Evolution of β-lactamase mediated cefiderocol resistance

2022-01-29

Abstract excerpt

<h4>ABSTRACT</h4> Cefiderocol is a novel siderophore β-lactam with improved hydrolytic stability toward β-lactamases, including carbapenemases, achieved by combining structural moieties of two clinically efficient cephalosporins, ceftazidime and cefepime. Consequently, cefiderocol represents a treatment alternative for infections caused by multi-drug resistant Gram-negatives. Using directed evolution on a wide va...

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Literature Corpus work
052a30bb-b62d-5b97-bc6b-30c6bf531c21
DOI
10.1101/2022.01.29.478156
Open publication

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Evolution of β-lactamase mediated cefiderocol resistanceDOI 10.1101/2022.01.29.478156
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