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Article

Effects of different carbapenemase and siderophore production on cefiderocol susceptibility in Klebsiella pneumoniae.

Antimicrobial agents and chemotherapy - 5 Dec 2024

Yang Chengcheng, Wang Liang, Lv Jingnan, Wen Yicheng, Gao Qizhao, Qian Feinan, Tian Xiangxiang, Zhu Jie, Zhu Zhichen, Chen Liang, Du Hong

Abstract excerpt

The resistance mechanism of Gram-negative bacteria to the siderophore antibiotic cefiderocol is primarily attributed to carbapenemase and siderophore uptake pathways; however, specific factors and their relationships remain to be fully elucidated. Here, we constructed cefiderocol-resistant Klebsiella pneumoniae (CRKP) strains carrying different carbapenemases and knocked out siderophore genes to investigate the...

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Identifiers

PMID: 39470196
DOI: 10.1128/aac.01019-24
PMCID: PMC11619314

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