Article
Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 9 Mar 2022
Klein Sabrina, Boutin Sébastien, Kocer Kaan, Fiedler Mascha O, Störzinger Dominic, Weigand Markus A, Tan Benjamin, Richter Daniel, Rupp Christian, Mieth Markus, Mehrabi Arianeb, Hackert Thilo, Zimmermann Stefan, Heeg Klaus, Nurjadi Dennis
Abstract excerpt
We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding a catecholate siderophore receptor, conferring phenotypic resistance to cefiderocol.
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- Carbapenems
- Cephalosporins
- Enterobacter cloacae
- Humans
- Microbial Sensitivity Tests
- Mutation
- Siderophores