Article

GPR56/ADGRG1 induces biased Rho-ROCK-MLC and JAK-STAT3 signaling to promote amoeboid-like morphology and IL-6 upregulation in melanoma cells

2024-06-05

Abstract excerpt

<title>Abstract</title> <p>Background GPR56/ADGRG1 is an adhesion G protein-coupled receptor that plays a role in cell-matrix interaction and metastasis of human melanoma cells. We have shown previously that GPR56 activation in melanoma cells triggers Gα<sub>12/13</sub>-RhoA signaling to promote IL-6 production and cell migration. Yet little is known of the downstream signaling effectors and their roles in modul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 63d066cc-dd75-51de-aaf7-a777ce0bbb01
DOI: 10.21203/rs.3.rs-4423390/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GPR56/ADGRG1 induces biased Rho-ROCK-MLC and JAK-STAT3 signaling to promote amoeboid-like morphology and IL-6 upregulation in melanoma cellsDOI 10.21203/rs.3.rs-4423390/v1Read

GPR56 interacts with extracellular matrix and regulates cancer progression.Semantic proximity Read

Orphan G protein–coupled receptor GPR56 plays a role in cell transformation and tumorigenesis involving the cell adhesion pathwaySemantic proximity Read

Downstream signaling of disease-associated mutations on GPR56/ADGRG1Semantic proximity Read

Downstream signalling of the disease-associated mutations on GPR56/ADGRG1.Semantic proximity Read

Functions of G protein‐coupled receptor 56 in health and diseaseSemantic proximity Read

GPR56/ADGRG1 Inhibits Mesenchymal Differentiation and Radioresistance in GlioblastomaSemantic proximity Read

GPR56: An adhesion GPCR involved in brain development, neurological disorders and cancer.Semantic proximity Read

GRK6 palmitoylation dictates triple-negative breast cancer metastasis via recruiting the β-Arrestin 2/MAPKs/NF-κB signaling axisSemantic proximity Read

Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation.Semantic proximity Read

GPR56/ADGRG1 regulates development and maintenance of peripheral myelin.Semantic proximity Read

Melanotransferrin Functions as a Pro-Oncogenic WNT Agonist: A Yin-Yang Relationship in Melanoma with the WNT Antagonist and Metastasis Suppressor, NDRG1Semantic proximity Read

Quantitative expression profiling of G‐protein‐coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug targetSemantic proximity Read