Article

Regional binding of tau and amyloid PET tracers in Down Syndrome autopsy brain tissue

2020-10-23

Abstract excerpt

<title>Abstract</title> <p><bold>INTRODUCTION</bold>: Tau pathology is a major age-related event in Down syndrome with Alzheimer’s disease (DS-AD). Although recently, several different Tau PET tracers have been developed as biomarkers for AD, these tracers showed different binding properties in Alzheimer disease and other non-AD tauopathies. They have not been yet investigated in tissue obtained <italic>postmorte...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 051d528f-44ca-5213-8968-f1f12f8dcdc6
DOI: 10.21203/rs.3.rs-48040/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Regional binding of tau and amyloid PET tracers in Down Syndrome autopsy brain tissueDOI 10.21203/rs.3.rs-48040/v2Read

AT(N) biomarker profiles and Alzheimer's disease symptomology in Down syndromeSemantic proximity Read

Joint-Label Fusion Brain Atlases for Dementia Research in Down SyndromeSemantic proximity Read

Longitudinal investigation for enhancing Down Syndrome Research (LIFE‐DSR) Study: Tau PET and CSF sub‐studiesSemantic proximity Read

Increased levels of plasma total tau in adult Down syndromeSemantic proximity Read

The striatum is an early, accurate indicator of amyloid burden using [<sup>11</sup>C]PiB in Down syndrome: comparison of two radiotracersSemantic proximity Read

Cryo-EM structures of amyloid-β and tau filaments in Down syndromeSemantic proximity Read

Tau Imaging with <sup>18</sup> F-MK6240 across the Alzheimer’s Disease spectrumSemantic proximity Read

[<sup>18</sup>F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasiaSemantic proximity Read

Brain perfusion patterns in familial frontotemporal lobar degeneration.Semantic proximity Read

[18F]AV‐1451 PET in behavioral variant frontotemporal dementia due to MAPT mutationSemantic proximity Read

Increased Dosage of Dyrk1A Alters Alternative Splicing Factor (ASF)-regulated Alternative Splicing of Tau in Down SyndromeSemantic proximity Read

In vivo 18F-AV-1451 tau PET signal in MAPT mutation carriers varies by expected tau isoforms.Semantic proximity Read