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AT(N) biomarker profiles and Alzheimer's disease symptomology in Down syndrome

28 Aug 2023

Abstract excerpt

INTRODUCTION: Down syndrome (DS) is a genetic cause of early-onset Alzheimer's disease (AD). The National Institute on Aging-Alzheimer's Association AT(N) Research Framework is a staging model for AD biomarkers but has not been assessed in DS. METHOD: F]AV-1451) were used to classify amyloid (A) -/+ and tau (T) +/-. Hippocampal volume classified neurodegeneration (N) -/+. The modified Cued Recall Test assessed...

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PMID: 37641428
DOI: 10.1002/alz.13446

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