Article
Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth.
Cell reports - 26 Dec 2023
Coleman Daniel J L, Keane Peter, Luque-Martin Rosario, Chin Paulynn S, Blair Helen, Ames Luke, Kellaway Sophie G, Griffin James, Holmes Elizabeth, Potluri Sandeep, Assi Salam A, Bushweller John, Heidenreich Olaf, Cockerill Peter N, Bonifer Constanze
Abstract excerpt
Acute myeloid leukemia (AML) is a heterogeneous disease caused by different mutations. Previously, we showed that each mutational subtype develops its specific gene regulatory network (GRN) with transcription factors interacting within multiple gene modules, many of which are transcription factor genes themselves. Here, we hypothesize that highly connected nodes within such networks comprise crucial regulators of...
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