Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth

Abstract excerpt

AML is a heterogenous disease caused by different mutations. We have previously shown that each mutational sub-type develops its specific gene regulatory network (GRN) with transcription factors interacting with multiple gene modules, many of which are transcription factor genes themselves. Here we hypothesized that highly connected nodes within such networks comprise crucial regulators of AML maintenance. We test...

Topics

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• Acute Myeloid Leukemia Research
• fms-Like Tyrosine Kinase 3
• Gene Regulatory Networks
• Leukemia, Myeloid, Acute
• Mutation
• Protein Degradation and Inhibitors
• Regulon
• RNA, Small Interfering

Identifiers and source

Literature Corpus work

5fe3266a-fcb8-52c4-9dd0-4301e1eb934a

DOI

10.1101/2023.07.18.549495