Article

Natural variation in a single amino acid underlies cellular responses to topoisomerase II poisons

2017-04-07

Abstract excerpt

<h4>ABSTRACT</h4> Many medications, including chemotherapeutics, are differentially effective from one patient to the next. Understanding the causes of these population-wide differences is a critical step towards the development of personalized treatments and improvements to existing medications. Here, we investigate natural differences in sensitivity to anti-neoplastic drugs that target topoisomerase II, using t...

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Literature Corpus work: 04eeffd3-9e1a-5bf5-a8ee-8a36b82268c1
DOI: 10.1101/125567

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