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Article

Natural diversity facilitates the discovery of conserved chemotherapeutic response mechanisms.

Current opinion in genetics & development - 1 Dec 2017

Zdraljevic Stefan, Andersen Erik C

Abstract excerpt

Organismal fitness depends on adaptation to complex niches where chemical compounds and pathogens are omnipresent. These stresses can lead to the fixation of alleles in both xenobiotic responses and proliferative signaling pathways that promote survival in these niches. However, both xenobiotic responses and proliferative pathways vary within and among species. For example, genetic differences can accumulate...

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Identifiers

PMID: 28892780
DOI: 10.1016/j.gde.2017.08.002
PMCID: PMC5716832

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