Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dengue virus activates cGAS through the release of mitochondrial DNA

9 Jun 2017

Abstract excerpt

Cyclic GMP-AMP synthetase (cGAS) is a DNA-specific cytosolic sensor, which detects and initiates host defense responses against microbial DNA. It is thus curious that a recent study identified cGAS as playing important roles in inhibiting positive-sense single-stranded RNA (+ssRNA) viral infection, especially since RNA is not known to activate cGAS. Using a dengue virus serotype 2 (DENV-2) vaccine strain (PDK53),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to interferon and immune responses
Share to Mosquito-borne diseases and control
Share to Viral Infections and Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28620207
DOI: 10.1038/s41598-017-03932-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dengue virus activates cGAS through the release of mitochondrial DNAPMID 28620207Read ↗

Collateral Damage during Dengue Virus Infection: Making Sense of DNA by cGASSemantic proximity Read ↗

Innate Immune Priming by cGAS as a Preparatory Countermeasure Against RNA Virus InfectionSemantic proximity Read ↗

Innate sensing of picornavirus infection involves cGAS-STING-mediated antiviral responses triggered by mitochondrial DNA releaseSemantic proximity Read ↗

DNA-induced 2′3′-cGAMP enhances haplotype-specific human STING cleavage by dengue proteaseSemantic proximity Read ↗

cGAS and STING: At the intersection of DNA and RNA virus-sensing networksSemantic proximity Read ↗

Crosstalk between RNA viruses and DNA sensors: Role of the cGAS‐STING signalling pathwaySemantic proximity Read ↗

Transmission of innate immune signaling by packaging of cGAMP in viral particlesSemantic proximity Read ↗

Regulation of cGAS‐Mediated Immune Responses and ImmunotherapySemantic proximity Read ↗

Viruses transfer the antiviral second messenger cGAMP between cellsSemantic proximity Read ↗

A miniature CRISPR-Cas10 enzyme confers immunity by an inverse signaling pathwaySemantic proximity Read ↗

Double-stranded RNA orbivirus disrupts the DNA-sensing cGAS-sting axis to prevent type I IFN inductionSemantic proximity Read ↗

cGAMP the travelling messengerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.