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Article

Defining requirements for heterodimerization between the retinoid X receptor and the orphan nuclear receptor Nurr1.

The Journal of biological chemistry - 20 Sept 2002

Aarnisalo Piia, Kim Chae-Hee, Lee Jae Woon, Perlmann Thomas

Abstract excerpt

Nurr1, an orphan nuclear receptor mainly expressed in the central nervous system, is essential for the development of the midbrain dopaminergic neurons. Nurr1 binds DNA as a monomer and exhibits constitutive transcriptional activity. Nurr1 can also regulate transcription as a heterodimer with the retinoid X receptor (RXR) and activate transcription in response to RXR ligands. However, the specific physiological...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Nuclear Receptor Subfamily 4, Group A, Member 2

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Source

Identifiers

PMID: 12130634
DOI: 10.1074/jbc.M201707200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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