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Maternal High Fat Diet and Diabetes Disrupts Transcriptomic Pathways that Regulate Cardiac Metabolism and Cell Fate in Newborn Rat Hearts

2020-05-29

Abstract excerpt

<title>Abstract</title> <p>Background Children born to diabetic or obese mothers have a higher risk of heart disease at birth and later in life. Our previous work using chromatin immunoprecipitation sequencing revealed that late-gestation diabetes in combination with maternal high fat (HF) diet cause a distinct fuel-mediated epigenetic reprogramming of rat cardiac tissue during fetal cardiogenesis. The objective...

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Literature Corpus work
e15d8544-2e89-5644-ab5f-6e2774f6e4dd
DOI
10.21203/rs.3.rs-30050/v1
Open publication

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Maternal High Fat Diet and Diabetes Disrupts Transcriptomic Pathways that Regulate Cardiac Metabolism and Cell Fate in Newborn Rat HeartsDOI 10.21203/rs.3.rs-30050/v1
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