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Role of Maternal Obesity in Offspring Cardiovascular Development and Congenital Heart Defects

2 May 2025

Abstract excerpt

Background Congenital heart disease is a leading cause of death in newborns, yet many of its molecular mechanisms remain unknown. Both maternal obesity and diabetes increase the risk of congenital heart disease in offspring, with recent studies suggesting these conditions may have distinct teratogenic mechanisms. The global prevalence of obesity is rising, and while maternal obesity is a known risk factor for...

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PMID: 40314345
DOI: 10.1161/jaha.124.039684

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