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Article

Maternal obesity persistently alters cardiac progenitor gene expression and programs adult-onset heart disease susceptibility

16 Nov 2020

Abstract excerpt

OBJECTIVE: Heart disease risk can be programmed by intrauterine exposure to obesity. Dysregulating key transcription factors in cardiac progenitors can cause subsequent adult-onset heart disease. In this study, we investigated the transcriptional pathways that are altered in the embryonic heart and linked to heart disease risk in offspring exposed to obesity during pregnancy. METHODS: Female mice were fed an...

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PMID: 33212270
DOI: 10.1016/j.molmet.2020.101116

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