Article

Sex-Dependent Epigenomic and Transcriptomic Reprogramming Links Maternal Obesity to Cardiac Remodeling in Adult Offspring

2025-04-19

Abstract excerpt

Maternal obesity during pregnancy predisposes the offspring to a high risk of developing cardiovascular and metabolic diseases later in life. This study investigated cardiac perturbations caused by maternal obesity by utilizing a mouse model of maternal high-fat diet (HFD)–induced obesity that recapitulates metabolic abnormalities observed in humans. Our study revealed that offspring of HFD-fed mothers (Off-HFD) e...

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Literature Corpus work: a0b2df84-0428-5458-b108-3e22928fddb2
DOI: 10.1101/2025.04.15.648971

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