Article
The programming of cardiac hypertrophy in the offspring by maternal obesity is associated with hyperinsulinemia, AKT, ERK, and mTOR activation.
Endocrinology - 1 Dec 2012
Fernandez-Twinn Denise S, Blackmore Heather L, Siggens Lee, Giussani Dino A, Cross Christine M, Foo Roger, Ozanne Susan E
Abstract excerpt
Human and animal studies suggest that suboptimal early nutrition during critical developmental periods impacts long-term health. For example, maternal overnutrition during pregnancy and lactation in mice programs insulin resistance, obesity, and endothelial dysfunction in the offspring. Here we investigated the effects of diet-induced maternal obesity on the offspring cardiac phenotype and explored potential...
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