Clonal transitions and phenotypic evolution in Barrett esophagus

Abstract excerpt

<h4>Background & Aims</h4> Barrett esophagus (BE) is a risk factor for the development of esophageal adenocarcinoma, however our understanding of how Barrett esophagus evolves is still poorly understood. We demonstrate that dynamic clonal phenotypic changes occur at the gland level, the mechanism by which these changes evolve, and how diversity may play a role in progression. <h4>Methods</h4> We analyzed the distr...

Topics

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• Adenocarcinoma
• Barrett Esophagus
• Electron Transport Complex IV
• Esophageal Cancer Research and Treatment
• Esophageal Neoplasms
• Loss of Heterozygosity
• Metaplasia
• Phenotype

Identifiers and source

Literature Corpus work

04be295c-3bd1-5389-96a5-df82c4edb41b

DOI

10.1101/2021.03.31.21252894