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Article

Clonal Transitions and Phenotypic Evolution in Barrett's Esophagus.

Gastroenterology - 1 Apr 2022

Evans James A, Carlotti Emanuela, Lin Meng-Lay, Hackett Richard J, Haughey Magnus J, Passman Adam M, Dunn Lorna, Elia George, Porter Ross J, McLean Mairi H, Hughes Frances, ChinAleong Joanne, Woodland Philip, Preston Sean L, Griffin S Michael, Lovat Laurence, Rodriguez-Justo Manuel, Huang Weini, Wright Nicholas A, Jansen Marnix, McDonald Stuart A C

Abstract excerpt

BACKGROUND & AIMS: Barrett's esophagus (BE) is a risk factor for esophageal adenocarcinoma but our understanding of how it evolves is poorly understood. We investigated BE gland phenotype distribution, the clonal nature of phenotypic change, and how phenotypic diversity plays a role in progression. METHODS: Using immunohistochemistry and histology, we analyzed the distribution and the diversity of gland phenotype...

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Identifiers

PMID: 34973296
DOI: 10.1053/j.gastro.2021.12.271
PMCID: PMC8972067

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