Article
High-Throughput Immunogenetics for Clinical and Research Applications in Immunohematology: Potential and Challenges.
Journal of immunology (Baltimore, Md. : 1950) - 15 May 2017
Langerak Anton W, Brüggemann Monika, Davi Frédéric, Darzentas Nikos, van Dongen Jacques J M, Gonzalez David, Cazzaniga Gianni, Giudicelli Véronique, Lefranc Marie-Paule, Giraud Mathieu, Macintyre Elizabeth A, Hummel Michael, Pott Christiane, Groenen Patricia J T A, Stamatopoulos Kostas
Abstract excerpt
Analysis and interpretation of Ig and TCR gene rearrangements in the conventional, low-throughput way have their limitations in terms of resolution, coverage, and biases. With the advent of high-throughput, next-generation sequencing (NGS) technologies, a deeper analysis of Ig and/or TCR (IG/TR) gene rearrangements is now within reach, which impacts on all main applications of IG/TR immunogenetic analysis. To...
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