Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux.

Abstract excerpt

OBJECTIVE: Strategies to inhibit or reverse cholesterol accumulation in macrophages have been shown to be atheroprotective. Notably, the administration of LXR agonists upregulates key players in the reverse cholesterol transport pathway, including the ABCA1 and ABCG1 transporters. However, the effects of natural LXR activators, oxysterols, on lipid-laden macrophages remains elusive. METHODS AND RESULTS: We...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Apolipoprotein A-I
• Share to ATP Binding Cassette Transporter 1