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A mutation in LXRα uncovers a role for cholesterol sensing in limiting metabolic dysfunction-associated steatohepatitis

28 Jan 2025

Abstract excerpt

Liver x receptor alpha (LXRα) functions as an intracellular cholesterol sensor that regulates lipid metabolism at the transcriptional level in response to the direct binding of cholesterol derivatives. We have generated mice with a mutation in LXRα that reduces activity in response to endogenous cholesterol derived LXR ligands while still allowing transcriptional activation by synthetic agonists. The mutant LXRα...

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Share to Cholesterol and Lipid Metabolism
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PMID: 39875396
DOI: 10.1038/s41467-025-56565-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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