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Article

SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism.

Cell metabolism - 7 Feb 2017

Oishi Yumiko, Spann Nathanael J, Link Verena M, Muse Evan D, Strid Tobias, Edillor Chantle, Kolar Matthew J, Matsuzaka Takashi, Hayakawa Sumio, Tao Jenhan, Kaikkonen Minna U, Carlin Aaron F, Lam Michael T, Manabe Ichiro, Shimano Hitoshi, Saghatelian Alan, Glass Christopher K

Abstract excerpt

Macrophages play pivotal roles in both the induction and resolution phases of inflammatory processes. Macrophages have been shown to synthesize anti-inflammatory fatty acids in an LXR-dependent manner, but whether the production of these species contributes to the resolution phase of inflammatory responses has not been established. Here, we identify a biphasic program of gene expression that drives production of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28041958
DOI: 10.1016/j.cmet.2016.11.009
PMCID: PMC5568699

Genes

TLR4

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