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Article

Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease.

Gastroenterology - 1 Mar 2011

Beaven Simon W, Wroblewski Kevin, Wang Jiaohong, Hong Cynthia, Bensinger Steven, Tsukamoto Hide, Tontonoz Peter

Abstract excerpt

BACKGROUND & AIMS: Liver X receptors (LXRs) are lipid-activated nuclear receptors with important roles in cholesterol transport, lipogenesis, and anti-inflammatory signaling. Hepatic stellate cells activate during chronic liver injury and mediate the fibrotic response. These cells are also major repositories for lipids, but the role of lipid metabolism during stellate cell activation remains unclear. We...

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Identifiers

PMID: 21134374
DOI: 10.1053/j.gastro.2010.11.053
PMCID: PMC3049833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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