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Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR-/- mice

2022-07-22

Abstract excerpt

<h4>ABSTRACT</h4> Fenretinide is a synthetic retinoid that can prevent obesity and improve insulin sensitivity in mice by directly altering retinol/retinoic acid homeostasis and inhibiting excess ceramide biosynthesis. We determined the effects of Fenretinide on LDLR -/- mice fed high-fat/high-cholesterol diet +/- Fenretinide, a model of atherosclerosis and non-alcoholic fatty liver disease (NAFLD). Fenretinide...

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Literature Corpus work
c8c2f79f-e493-5c1e-bdfb-b76e1c9c9001
DOI
10.1101/2022.07.22.500933
Open publication

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Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR-/- miceDOI 10.1101/2022.07.22.500933
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