Article

Propionyl-CoA carboxylase subunit B regulates anti-tumor T cells in a pancreatic cancer mouse model

2023-07-26

Abstract excerpt

<h4>ABSTRACT</h4> Most human pancreatic ductal adenocarcinoma (PDAC) are not infiltrated with cytotoxic T cells and are highly resistant to immunotherapy. Over 90% of PDAC have oncogenic KRAS mutations, and phosphoinositide 3-kinases (PI3Ks) are direct effectors of KRAS. Our previous study demonstrated that ablation of Pik3ca in KPC ( Kras G12D ; Trp53 R172H ; Pdx1-Cre ) pancreatic cancer cells induced host T...

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Literature Corpus work: 046d57d8-d0f0-5761-adc7-5bb3011c0dc4
DOI: 10.1101/2023.07.24.550301

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