Article

Plectin promotes an aggressive phenotype and represses cytotoxic T cell activity in pancreatic cancer

2026-04-20

Abstract excerpt

<h4>Background</h4> Pancreatic adenocarcinoma (PDAC) is an abysmal disease, with a poor clinical outcome, largely due to limited life-extending treatments for patients. Notoriously, PDAC displays a T cell-suppressive tumor microenvironment where underlying molecular mechanisms that lead to this phenotype remain poorly understood. To unravel specific mechanisms, we utilized bioinformatic analyses with functional s...

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Literature Corpus work: 0539fa45-312c-5074-9bcb-52611e9199d5
DOI: 10.64898/2026.04.16.718901

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