Article

Clinically relevant orthotopic pancreatic cancer models for adoptive T cell therapy

2023-09-10

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumor. Prognosis is poor and survival is low in patients diagnosed with this disease; ∼12% at 5 years. Immunotherapy, including adoptive T cell transfer therapy, has not impacted outcomes in PDAC patients, due in part to the hostile tumor microenvironment (TME) which limits T cell trafficking and persistence. We posit that murine models serve as useful tools...

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Literature Corpus work: acbbc367-bcfb-5bd4-9a41-81c0226e9bb3
DOI: 10.1101/2023.09.07.556707

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