Article

Disruption of Z-RNA–binding of ADAR1 induces Aicardi-Goutières syndrome–like encephalopathy in mice

2020-12-16

Abstract excerpt

<h4>SUMMARY</h4> ADAR1 p150 is an enzyme responsible for adenosine-to-inosine RNA editing. Deletion of ADAR1 p150 results in embryonic lethality with a type I interferon (IFN) signature, caused by aberrant MDA5 sensing unedited transcripts. ADAR1 p150 contains a unique Z-DNA/RNA–binding domain α (Zα); however, the role of this domain remains unknown. A mutation has been identified in this domain in patients with...

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Literature Corpus work: 3f440247-f6b5-52b1-a819-2a7107891851
DOI: 10.1101/2020.12.16.422984

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Disruption of Z-RNA–binding of ADAR1 induces Aicardi-Goutières syndrome–like encephalopathy in miceDOI 10.1101/2020.12.16.422984Read

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