Article

Z-Form Stabilization By The Zα Domain Of Adar1p150 Has Subtle Effects On A-To-I Editing

2025-06-04

Abstract excerpt

The role of Adenosine Deaminase Acting on RNA 1 (ADAR1)’s Z-conformation stabilizing Zα domain in A-to-I editing is unclear. Previous studies on Zα mutations faced limitations, including variable ADAR1p150 expression, differential editing analysis challenges, and unaccounted changes in ADAR1p150 localization. To address these issues, we developed a Cre-lox system in ADAR1p150 KO cells to generate stable cell lines...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: db6ba446-bcd1-53c9-8a87-ce2b423d93c5
DOI: 10.1101/2025.06.02.657529

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Z-Form Stabilization By The Zα Domain Of Adar1p150 Has Subtle Effects On A-To-I EditingDOI 10.1101/2025.06.02.657529Read

Disruption of Z-RNA–binding of ADAR1 induces Aicardi-Goutières syndrome–like encephalopathy in miceSemantic proximity Read

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activationSemantic proximity Read

Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy.Semantic proximity Read

The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoformsSemantic proximity Read

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation.Semantic proximity Read

RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicingSemantic proximity Read

Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses.Semantic proximity Read

ADAR1 Zα domain P195A mutation activates the MDA5-dependent RNA-sensing signaling pathway in brain without decreasing overall RNA editing.Semantic proximity Read

The most common human ADAR1p150 Zα domain mutation P193A is well tolerated in mice and does not activate the integrated stress response pathwaySemantic proximity Read

Generation of a new <i> Adar1p150 <sup>-/-</sup> </i> mouse demonstrates isoform-specific roles in embryonic development and adult homeostasisSemantic proximity Read

Decoupling expression and editing preferences of ADAR1 p150 and p110 isoforms.Semantic proximity Read

Functions of the RNA Editing Enzyme ADAR1 and Their Relevance to Human DiseasesSemantic proximity Read