Article

Z-Flipon Variants reveal the many roles of Z-DNA and Z-RNA in health and disease

2023-01-13

Abstract excerpt

Identifying roles for Z-flipons remains challenging given their dynamic nature. Here we perform genome-wide interrogation with the DNABERT transformer algorithm trained on experimentally identified Z-DNA sequences. We show Z-flipons are enriched in promoters and telomeres and overlap quantitative trait loci for RNA expression, RNA editing, splicing and disease associated variants. Surprisingly, many effects are me...

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Literature Corpus work: 5c44a364-e77c-5405-b351-0db37d0a7502
DOI: 10.1101/2023.01.12.523822

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