Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biological consequences of Z-nucleic acid sensing by ZBP1 and ADAR1.

RNA biology - 1 Dec 2026

Lu Fei, Tang Linghuan, Kim Chun, Lai Dengming, Tou Jinfa, Jiao Huipeng

Abstract excerpt

Since their discovery, Z-nucleic acids (Z-NAs), which adopt a left-handed double helical conformation, have puzzled researchers regarding their physiological functions. These unusual nucleic acids are recognized by proteins containing Zα domains, particularly Z-DNA binding protein 1 (ZBP1) and adenosine deaminase acting on RNA 1 (ADAR1). Utilizing mouse genetics with knockout models and site-specific Zα domain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Deaminase
Share to DNA-Binding Proteins
Share to Inflammation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Protein Binding

Share to RNA-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 42311118
DOI: 10.1080/15476286.2026.2691476
PMCID: PMC13313186

Genes

ZBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biological consequences of Z-nucleic acid sensing by ZBP1 and ADAR1.PMID 42311118Read ↗

Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses.Semantic proximity Read ↗

ADAR1 averts fatal type I interferon induction by ZBP1.Semantic proximity Read ↗

ZBP1: A Powerful Innate Immune Sensor and Double-Edged Sword in Host ImmunitySemantic proximity Read ↗

The Role of the Z-DNA Binding Domain in Innate Immunity and Stress GranulesSemantic proximity Read ↗

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation.Semantic proximity Read ↗

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activationSemantic proximity Read ↗

ADAR1 mutation causes ZBP1-dependent immunopathology.Semantic proximity Read ↗

Z-DNA-binding protein 1-mediated programmed cell death: Mechanisms and therapeutic implicationsSemantic proximity Read ↗

Emerging Role of ZBP1 in Z-RNA Sensing, Influenza Virus-Induced Cell Death, and Pulmonary InflammationSemantic proximity Read ↗

Z-form nucleic acid-binding protein 1 (ZBP1) as a sensor of viral and cellular Z-RNAs: walking the razor's edgeSemantic proximity Read ↗

Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy.Semantic proximity Read ↗

ADAR1 and ZBP1 in innate immunity, cell death, and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.