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The Role of the Z-DNA Binding Domain in Innate Immunity and Stress Granules

3 Feb 2021

Abstract excerpt

Both DNA and RNA can maintain left-handed double helical Z-conformation under physiological condition, but only when stabilized by Z-DNA binding domain (ZDBD). After initial discovery in RNA editing enzyme ADAR1, ZDBD has also been described in pathogen-sensing proteins ZBP1 and PKZ in host, as well as virulence proteins E3L and ORF112 in viruses. The host-virus antagonism immediately highlights the importance of...

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PMID: 33613567
DOI: 10.3389/fimmu.2020.625504

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