Article
Integrated Genomic Analysis Identifies Driver Genes and Cisplatin-Resistant Progenitor Phenotype in Pediatric Liver Cancer.
Cancer discovery - 1 Oct 2021
Hirsch Theo Z, Pilet Jill, Morcrette Guillaume, Roehrig Amélie, Monteiro Benedict J E, Molina Laura, Bayard Quentin, Trépo Eric, Meunier Léa, Caruso Stefano, Renault Victor, Deleuze Jean-François, Fresneau Brice, Chardot Christophe, Gonzales Emmanuel, Jacquemin Emmanuel, Guerin Florent, Fabre Monique, Aerts Isabelle, Taque Sophie, Laithier Véronique, Branchereau Sophie, Guettier Catherine, Brugières Laurence, Rebouissou Sandra, Letouzé Eric, Zucman-Rossi Jessica
Abstract excerpt
Pediatric liver cancers (PLC) comprise diverse diseases affecting infants, children, and adolescents. Despite overall good prognosis, PLCs display heterogeneous response to chemotherapy. Integrated genomic analysis of 126 pediatric liver tumors showed a continuum of driver mechanisms associated with patient age, including new targetable oncogenes. In 10% of patients with hepatoblastoma, all before three years...
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