Back to search

Article

Progression GWAS followed by functional characterization implicates E3 ubiquitin ligase<i>TRIM2</i>as a potential genetic modifier of Parkinson’s disease progression

2025-02-23

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson’s Disease (PD) is a progressive neurodegenerative disorder, affecting 10 million people worldwide. While genome-wide association studies (GWAS) have identified many genetic variants associated with PD incidence, the genetics underlying PD progression are poorly understood. Here, we aim to address this gap by performing GWAS on longitudinal clinical metrics from well-defined PD cohorts....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0423b400-61d2-5fb0-9afb-7486f73fb954
DOI
10.1101/2025.02.21.25322301
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Progression GWAS followed by functional characterization implicates E3 ubiquitin ligase<i>TRIM2</i>as a potential genetic modifier of Parkinson’s disease progressionDOI 10.1101/2025.02.21.25322301
Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease.Semantic proximity
Identification of Parkinson’s disease PACE subtypes and repurposing treatments through integrative analyses of multimodal dataSemantic proximity
The Foundational data initiative for Parkinson’s disease (FOUNDIN-PD): enabling efficient translation from genetic maps to mechanismSemantic proximity
Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration.Semantic proximity
Identification of Parkinson PACE subtypes and repurposing treatments through integrative analyses of multimodal clinical progression, neuroimaging, genetic, and transcriptomic dataSemantic proximity
Evaluation Of The <i>Rims2</i> Locus As A Risk Locus For Parkinson’s Disease DementiaSemantic proximity
Parietal Cortex Transcriptomics Refines Parkinson Disease GWAS Nomination and Highlights STAT3 as a Putative Upstream Glial RegulatorSemantic proximity
Mapping Parkinson’s Disease Progression through Deep Plasma Proteomics and Functional GenomicsSemantic proximity
<i>TMEM175, SCARB2</i> and <i>CTSB</i> associations with Parkinson’s disease risk across populationsSemantic proximity
From Neural Connectopathy to a Therapeutic Path: An Integrated Multi-omics Framework Identifies a Causal Gene and Drug Candidates for Parkinson's Disease with mild cognitive impairmentSemantic proximity
Longitudinal Epigenome-Wide Methylation Study of Cognitive Decline and Motor Progression in Parkinson’s DiseaseSemantic proximity
Identification of Parkinson’s disease-associated regulatory variants in human dopaminergic neurons reveals modulators of <i>SCARB2</i> and <i>BAG3</i> expressionSemantic proximity
Select a neighboring publication to make it the new centre.