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From Neural Connectopathy to a Therapeutic Path: An Integrated Multi-omics Framework Identifies a Causal Gene and Drug Candidates for Parkinson's Disease with mild cognitive impairment

2025-11-18

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<title>Abstract</title> <p> Background Parkinson’s disease with mild cognitive impairment (PD-MCI) represents a devastating outcome for patients, yet its pathogenic drivers remain poorly understood, and predictive biomarkers are critically lacking. This study aims to establish an early diagnostic model for PD-MCI (from PD), delineate causal mechanisms and identify translational opportunities for PD-MCI. Methods...

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Literature Corpus work
9dcd66e6-1850-57fa-b80b-d61f06631cbb
DOI
10.21203/rs.3.rs-7937441/v1
Open publication

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From Neural Connectopathy to a Therapeutic Path: An Integrated Multi-omics Framework Identifies a Causal Gene and Drug Candidates for Parkinson's Disease with mild cognitive impairmentDOI 10.21203/rs.3.rs-7937441/v1
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