Article
Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America - 19 Aug 2008
Balastik Martin, Ferraguti Francesco, Pires-da Silva André, Lee Tae Ho, Alvarez-Bolado Gonzalo, Lu Kun Ping, Gruss Peter
Abstract excerpt
TRIM RING finger proteins have been shown to play an important role in cancerogenesis, in the pathogenesis of some human hereditary disorders, and in the defense against viral infection, but the function of the majority of TRIM proteins remains unknown. Here, we show that TRIM RING finger protein TRIM2, highly expressed in the nervous system, is an UbcH5a-dependent ubiquitin ligase. We further demonstrate that...
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