Article

Abnormal ventricular wall patterning precedes and drives MYBPC3 hypertrophic cardiomyopathy

2026-03-30

Abstract excerpt

<h4>BACKGROUND</h4> Excessive trabeculations and myocardial crypts are recurrent features across cardiomyopathies, yet their developmental origins and clinical significance remain poorly defined. To reveal the link between cardiac morphogenesis and disease, we generated humanized mouse models carrying patient-derived MYBPC3 frameshift mutations associated with overlapping hypertrophic cardiomyopathy (HCM) and le...

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Literature Corpus work: 3308a094-7aab-53ae-8d22-6eaddba01728
DOI: 10.64898/2026.03.25.714341

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