Article
Genetic variation in G-protein-coupled receptors--consequences for G-protein-coupled receptors as drug targets.
Expert opinion on therapeutic targets - 1 Dec 2005
Tang Chih-Min, Insel Paul A
Abstract excerpt
G-protein-coupled receptors (GPCRs), including 'orphan' GPCRs whose natural ligands are unknown, comprise the largest membrane receptor superfamily and are the most commonly used therapeutic targets. GPCR genetic loci harbour numerous variants, such as DNA insertions or deletions and single nucleotide polymorphisms that alter GPCR expression and function, thereby contributing to inter-individual differences in...
Topics
- Drug Delivery Systems
- Genetic Variation
- Humans
- Polymorphism, Genetic
- Receptors, G-Protein-Coupled