The novel endosomal membrane protein Ema interacts with the class C Vps–HOPS complex to promote endosomal maturation

Abstract excerpt

Endosomal maturation is critical for accurate and efficient cargo transport through endosomal compartments. Here we identify a mutation of the novel Drosophila gene, ema (endosomal maturation defective) in a screen for abnormal synaptic overgrowth and defective protein trafficking. Ema is an endosomal membrane protein required for trafficking of fluid-phase and receptor-mediated endocytic cargos. In the ema...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cellular transport and secretion
• Share to Lysosomal Storage Disorders Research
• Share to Plant Reproductive Biology