Article

ESCRT disruption provides evidence against signaling functions for synaptic exosomes

2023-04-24

Abstract excerpt

Extracellular vesicles (EVs) are released by many cell types including neurons, carrying cargoes involved in signaling and disease. It is unclear whether EVs promote intercellular signaling or serve primarily to dispose of unwanted materials. We show that loss of multivesicular endosome-generating ESCRT (endosomal sorting complex required for transport) machinery disrupts release of EV cargoes from Drosophila moto...

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Literature Corpus work: df269949-de2c-569f-9c76-27b61cce1ecc
DOI: 10.1101/2023.04.22.537920

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