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Article

Efficient Implementation of Penalized Regression for Genetic Risk Prediction

26 Feb 2019

Abstract excerpt

Polygenic Risk Scores (PRS) combine genotype information across many single-nucleotide polymorphisms (SNPs) to give a score reflecting the genetic risk of developing a disease. PRS might have a major impact on public health, possibly allowing for screening campaigns to identify high-genetic risk individuals for a given disease. The "Clumping+Thresholding" (C+T) approach is the most common method to derive PRS....

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PMID: 30808621
DOI: 10.1534/genetics.119.302019

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